Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential
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چکیده
منابع مشابه
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.
BACKGROUND Bradycardic agents are of interest for the treatment of ischemic heart disease and heart failure, as heart rate is an important determinant of myocardial oxygen consumption. OBJECTIVES The purpose of this study was to investigate the propensity of hydroxychloroquine (HCQ) to cause bradycardia. METHODS We assessed the effects of HCQ on (1) cardiac beating rate in vitro (mice); (2)...
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2015
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2015.05.027